Physicians of the Zane Cohen Centre

Erin D. Kennedy, M.D., PhD, F.R.C.S.(C)

Colorectal Surgeon

Dr. Erin Kennedy  Dr. Kennedy is a Colorectal Surgeon at Mount Sinai Hospital and researcher at Mount Sinai’s Samuel Lunenfeld Research Institute. Additionally, she is an Assistant Professor in the Department of Surgery and the Institute of Health Policy, Management and Evaluation. Her clinical interest is in the treatment of colorectal cancer. Erin is an internationally recognized expert in Patient Centred Care, Qualitative Research Methods and Shared Decision Making in Surgery and has been successful at developing a wide collaborative network both locally, provincially and nationally.

Dr. Kennedy has an excellent record of grant capture and publications including PI on 2 Canadian Institute of Heath Research (CIHR) grants and other peer reviewed grants. In April 2010, she was recognized as the Researcher of the Month by the Canadian Cancer Society. Erin Teaches a graduate course on the measurement of patients’ preferences in health care decision making at the University of Toronto.

Centre
Zane Cohen Centre for Digestive Diseases

Contact
Clinic Office
Mount Sinai Hospital
455-600 University Ave.
Toronto, ON   M5G 1X5
E-mail: Erin.Kennedy@SinaiHealthSystem.ca

Administrative Assistant
David Woodley
Phone: 416-586-4800 x 6872
Fax: 416-586-1586
E-mail: David.Woodley@SinaiHealthSystem.ca

Research Office
Zane Cohen Centre for Digestive Diseases
60 Murray Street, L3-007, Box 23
Toronto, ON M5T 3L9

Research Coordinator
Selina Schmocker
Phone: 416-586-4800 x 2159
Fax: 416-586-5932
E-mail: sschmocker@mtsinai.on.ca


Publications
PA-Principal Author; SRI-Senior Responsible Investigator; CPA-Co-Principal Author; C-Collaborator

  • Kennedy ED, Blair JE, Ready R, Wolff BG, Steinhart AH, Carryer PW, McLeod RS: Patients' perceptions of their participation in a clinical trial for postoperative Crohn's disease.  Canadian Journal of Gastroenterology 1998;12:287-291.  PA
  • Brenneman FD, Wright JG, Kennedy ED, McLeod RS: Outcomes research in surgery.  World Journal of Surgery 1999;23:1210-1214.  C
  • Urbach DR, Kennedy ED, Cohen MM: Colon and rectal anastomoses do not require routine drainage.  Annals of Surgery 1999;29:172-180.  C
  • Kennedy ED, Detsky AS, Llewellyn-Thomas HA, O'Connor BI, Varkul M, Steinhart AH, Cohen Z, McLeod RS: Can the standard gamble be used to determine the utility for uncertain health states? An example using post-operative maintenance therapy in Crohn's disease.  Medical Decision Making 2000;20:72-78.  PA
  • MacLean AR, O'Connor BI, Mukraj D, Kennedy ED, Parkes R, MacRae HM, Cohen Z, McLeod RS: Risk of small bowel obstruction following ileoanal pouch anastomosis.  Annals of Surgery 2002;235:200-206.  C
  • Kennedy ED, Urbach DR, Krahn M, Cohen Z, Steinhart AH, McLeod RS: Azathioprine or ileocolic resection for steroid dependent terminal ileal Crohn's disease? A decision analysis.  Diseases of the Colon and Rectum 2004;47:2120-2130.  PA
  • Kennedy ED, Rothwell DM, MacRae HM, Cohen Z, McLeod RS: Increased experience and surgical technique lead to improved outcome after ileal pouch-anal anastomosis: a population based study.  Diseases of the Colon and Rectum 2006;49:958-965.  PA
  • Kennedy ED, To T, Steinhart AH, Detsky AS, Llewellyn-Thomas HA, McLeod RS: Do patients consider post-operative maintenance therapy for Crohn's disease worthwhile? Inflammatory Bowel Diseases 2008;14:224-235.  PA
  • Nenshi R, Urbach DR, Simunovic M, Baxter N, Gunraj N, Kennedy ED, Schultz S, Wilton D: Colon and Rectal Cancer Surgery.  In: Atlas of Cancer Surgery in Ontario. Cancer Care Ontario, Toronto. 2008.  C
  • McLeod RS, Schmocker S, Kennedy ED: Management of colon cancer in the elderly.  Geriatrics and Aging 2009;12:374-381.  PA
  • Spiegle G, Leon-Carlyle M, Schmocker S, Fruitman M, Milot L, Gagliardi A, Smith A, McLeod R, Kennedy ED: Development of a synoptic MRI report for primary rectal cancer.  Implementation Science 2009;4:6.  SRI
  • Leon-Carlyle M, Spiegle G, Schmocker S, Gagliardi A, Urbach D, Kennedy E: Using patient and physician perspectives to develop a shared decision making framework for colorectal cancer.  Implementation Science 2009;4;5.  SRI
  • Chetty R, Serra S, Kennedy ED, Govender D: Oncocytic rectal adenocarcinomas. Human Pathology 2009: 40(4): 478-483. C
  • Kennedy ED: Management of the low risk malignant polyp - is watchful waiting the best option? Diseases of the Colon and Rectum 2010;53:2.  PA
  • Brace C, Schmocker S, Huang H, Victor C, McLeod RS, Kennedy ED: Physicians' awareness and attitudes towards decision aids for patients with cancer.  Journal of Clinical Oncology 2010;28:2286-92.  SRI
  • Kennedy, ED: Reply to D Vordermark.  Journal of Clinical Oncology 2010;28(29): p e 568  PA
  • Kennedy ED: Management of the primary in stage IV disease.  Audio-Digest General Surgery 2010: 57.  PA
  • Sandroussi C, Brace C, Kennedy ED, Baxter NN, Gallinger S, Wei AC: Sociodemographics and comorbidities influence decisions to undergo pancreatic resection for neoplastic lesions.  Journal of Gastrointestinal Surgery 2010;14:401-1208.  C
  • Larissa K. Temple, Erin D. Kennedy, Clifford Y. Ko: Canadian Association of General Surgeons, the American College of Surgeons, the Canadian Society of Colorectal Surgeons and the American Society of Colorectal Surgeons: Evidence Based Reviews in Surgery - Colorectal Surgery.  Diseases of the Colon and Rectum 2011;54:501-503. C
  • Kennedy ED, Schmocker S, Victor C, Baxter N, Kim, J, Brierley J, McLeod RS: Do   patients consider pre-operative chemoradiation for primary rectal cancer worthwhile? Cancer 2011; 117(13): 2853-2862. PA
  • Roy P, Serra S, Kennedy ED, Chetty R: The prognostic value of grade of regression and oncocytic change in rectal adenocarcinoma treated with neo-adjuvant chemoradiotherapy. Journal of Surgical Oncology 2012; 105(2):130-4. doi: 10.1002/jso.22073. Epub 2011 Aug 12. C
  • Al-Sukhni E, Milot L, Fruitman M, Beyene J, Victor JC, Schmocker S, Brown G, McLeod RS, Kennedy ED: Diagnostic accuracy of MRI for assessment of T-category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis. Annals of Surgical Oncology 2012: DOI 10.1245/s10434-011-2210-5. SRI
  • Spiegle G, Al-Sukhni E, Schmocker S, Gagliardi AR, Victor JC, Baxter NN, Kennedy ED: Patient decision aids for cancer treatment: are there any alternatives? Accepted for publication in Cancer (February 2012). SRI


Submitted Manuscripts

  • Spiegle G, Schmocker S, Huang H, Victor JC, Law C,  McCart AJ, Kennedy ED: Physicians' Awareness of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Cancer Carcinomatosis. Submitted to the Canadian Journal of Surgery (February 2012). SRI

Kenneth Croitoru, MDCM, FRCPC

Dr. Kenneth CroitoruDr. Kenneth Croitoru joined the Division of Gastroenterology at Mount Sinai Hospital in January 2008. He completed medical school at McGill University in 1981 and trained in internal medicine and gastroenterology from 1982-1986. He went on to do post-doctoral training as an MRC Research Fellow in Mucosal Immunology with Dr. John Bienenstock at McMaster University. On completion of this research training he joined the Division of Gastroenterology at McMaster in 1992 where he went on to serve as Training Program Director and Associate Director of the Division. During this time he developed his research program with funding from the Canadian Institute of Health Research, Canadian Association of Gastroenterology and the Crohn's and Colitis Foundation of Canada. He held an Ontario Ministry of Health Career Scientist award for 10 years and more recently was one of the first recipients of a 5 year CCFC IBD Research Scientist Award. He served as the Chair of the CCFC Medical Advisory Board and helped develop the CCFC IBD Research Institute where he served as Chair of the Executive Committee until 2008.

Dr. Croitoru joined the Department of Medicine at Mount Sinai Hospital as a Clinician Scientist in 2008 and is appointed to the Lunenfeld-Tannenbaum Research Institute. He is also a full Professor of Medicine at the University of Toronto, a member of the Institute of Medical Sciences and has a cross-appointment in the Department of Immunology.

His research is focused on investigating the fundamental mechanisms of intestinal inflammation, in particular the role of T cell effector and regulatory function in the intestinal mucosal in Inflammatory Bowel Disease (IBD). The goal of his work is to understand how T cells function to maintain intestinal homeostasis in health and what defects in regulatory T cells allow for the breakdown of these mechanisms.

Dr. Croitoru is also Project Leader of, the GEM Project (www.GEMPROJECT.ca) a global clinical study that is coordinated out of the IBD Research Group and Zane Cohen Center at Mount Sinai Hospital. The study is a prospective cohort study of healthy subjects at risk of developing Crohn's disease. That will explore the Genetic, Environmental and Microbial factors that lead to Cohn's disease. This study has had over $15 million in funding from Crohn's Colitis Canada, CIHR and the Helmsley Charitable Trust.


Centre
Mount Sinai Hospital
Zane Cohen Centre for Digestive Diseases
Inflammatory Bowel Diseases (IBD) Group

Contact
Phone: 416-586-4800 ext. 7454
Fax: 416-586-4747
E-mail: Ken.Croitoru@SinaiHealthSystem.ca

Administrative Secretary
Tammie Greenslade
Phone: 416-586-4800 ext. 7454
Fax: 416-586-4747
E-mail: Tammie.Greenslade@SinaiHealthSystem.ca


Office Location
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Centre
437-600 University Avenue
Toronto, Ontario, Canada
M5G 1X5

Board Certificates
Royal College Certificate in Internal Medicine and Gastroenterology
Specialist Certificate, Quebec, Internal Medicine and Gastroenterology
American Board of Internal Medicine Certification

Professional Organizations

American Gastroenterological Association
American Association of Immunologists
Canadian Association of Gastroenterology
Canadian Association for the Study of the Liver
Canadian Medical Association
Canadian Society for Immunology
Crohn’s and Colitis Foundation of Canada (Professional Member)
Ontario Association of Gastroenterology
Ontario Medical Association
Society for Mucosal Immunology

Publications

  • Vallance, B.A., Croitoru, K. and Collins, S.M.  T lymphocyte-dependent and -independent intestinal smooth muscle dysfunction in the T. spiralis infected mouse.  American Journal of Physiology 38:G1157-1165, 1998.
  • Xing, Z., Wang, J., Croitoru, K. and Wakeham, J.  Protection by CD4 or CD8 T cells against pulmonary Mycobacterium bovis Bacillus Calmette-Guerin infection.  Infection and Immunity 66:5537-5542, 1998.
  • Radojevic, N., McKay, D.M., Merger, M., Vallance, B.A., Collins, S.M. and Croitoru, K.  Characterization of enteric functional changes evoked by In vivo anti-CD3 T cell activation. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 45:R715-R723, 1999.
  • Bo, J., Jordana, M., Xing, Z., Smaill, F., Snider, D.P., Borojevic, R., Steele-Norwood, D., Hunt, R.H. and Croitoru, K.  Replication defective adenovirus infection reduces Helicobacter felis colonization in the mouse in an interferon-? and IL-12 dependent manner.  Infection and Immunity 67:4539-4544, 1999.
  • Merger M, Viney JL, Borojevic R, Steele-Norwood D, Zhou P, Clark DA, Riddell R, Maric R, Podack ER, Croitoru, K.  Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine.  Gut 51:155-163, 2002.
  • Steinhart, A.H., Feagan, B.G., Wong, C.J., Vandervoort, M., Mikolainis, S., Croitoru, K., Seidman, E., Leddin, D.J., Bitton, A., Drouin, E., Cohen, A. and Greenberg, G.R. Combination Budesonide and antibiotic therapy for active Crohn’s disease: a randomized controlled trial. Gastroenterology 123(1):33-40, 2002.
  • Streutker, C.J., Bernstein, C.N., Chan, V.L., Riddell, R.H. and Croitoru, K.  Detection of species-specific Helicobacter ribosomal DNA in intestinal biopsy samples from a population-based cohort of patients with ulcerative colitis.  Journal of Clinical Microbiology 42(2):660-664, 2004.
  • Zhou, P., Borojevic, R., Streutker, C., Snider, D., Liang, H. and Croitoru, K.  Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens.  Journal of Immunology 172:1515-1523, 2004.
  • Soderholm, J.D., Streutker, C., Yang, P.-C., Paterson, C., Singh, P.K., McKay, D.M., Sherman, P.M., Croitoru, K. and Perdue, M.H.  Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor a.  Gut 53:1817-1824, 2004.
  • Zhou, P., Streutker, C., Borojevic, R., Wang, Y. and Croitoru, K.  IL-10 modulates intestinal damage and epithelial cell apoptosis in T cell-mediated enteropathy.  American Journal of Physiology-Gastrointestinal and Liver Physiology, 287:G599-G604, 2004.
  • Mow, W.S., Landers, C.J., Steinhart, A.H., Feagan, B.G., Croitoru, K., Seidman, E., Greenberg, G.R. and Targan, S.R. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn’s disease: a pilot study.  Digestive Diseases and Sciences 49:1280-1286, 2004.
  • Croitoru, K. and Zhou, P.  T-cell-induced mucosal damage in the intestine.  Current Opinion in Gastroenterology 20:581-586, 2004.
  • Panaccione, R., Fedorak, R.N., Aumais, G., Bernstein, C.N., Bitton, A., Croitoru, K., Enns, R., Feagan, B., Fishman, M., Greenberg, G., Griffiths, A., Marshall, J.K., Rasul, I., Sadowski, D., Seidman, E., Steinhart, H., Sutherland, L., Walli, E., Wild, G., Williams, C.N. and Zachos, M.  Canadian Association of Gastroenterology Clinical Practice Guidelines: the use of infliximab in Crohn’s disease.  Canadian Journal of Gastroenterology 18:503-508, 2004.
  • Shin, J.L., Teitel, J., Swain, M.G., Bain, V.G., Adams, P.C., Croitoru, K., Peltekian, K., Schweiger, F., Simons, M.E. and Heathcote, EJ.  A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: Is it safe and useful?  American Journal of Hematology 78:85-93, 2005.
  • Alvarez, D., Swirski, F.K., Yang, T-C., Fattouh, R., Croitoru, K., Bramson, J.L., Stämpfli, M.R. and Jordana, M. Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and non-mucosal tissues. Journal of Immunology 176:2568-2580, 2006.
  • Bharhani, M.S., Borojevic, R., Basak, S., Ho, E., Zhou, P. and Croitoru, K.  IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression.  Am J Physiol Gastrointest Liver Physiol 291:820-829, 2006.
  • Mauro, M., Radovic, V., Zhou, P., Wolfe, M., Kamath, M., Bercik, P. Croitoru, K. and Armstrong, D.  13C urea breath test for Helicobacter pylori: Determination of the optimal cut-off point in a Canadian community population.  The Canadian Journal of Gastroenterology 20:770-774, 2006.
  • Chatterjee A, Swain MG, Lee SS, Bain VG, Peltekian K, Croitoru K, Adams PC, Kaita K, Teitel J and Heathcote EJ.  Induction versus noninduction antiviral therapy for chronic hepatitis C virus in patients with congenital coagulation disorders: a Canadian multicentre trial.  The Canadian Journal of Gastroenterology 21(2):91-95, 2007.
  • Wu L, Feng BS, He SH, Zheng PY, Croitoru K, Yang PC. Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2. Immunology and Cell Biology. Oct; 85(7):538-45, 2007.
  • Panancionne, R., Fedorak, R. N., Aumais, G., Bernard, E. J., Bernstein, C. N., Bitton, A., Croitoru, K., Dieleman, L. A., Enns, R., Feagan, B. G., Franchimont, D., Greenberg, G. R. Griffiths, A. M., Marshall, J. K., Pare, P., Patel, S., Penner, R., Render, C., Seidman, E., Steinhart, A. H. Review and Clinical Perspectives for the use of Infliximab in Ulcerative Colitis.  The Canadian Journal of Gastroenterology 22(3):261-272, 2008.
  • Verdu, E.F., Bercik, P., Huang, X.X., Lu, J., Al-Mutawaly, N., Sakai, H., Tompkins, T. A., Croitoru, K., Tsuchida, E., Perdue, M., Collins, S. M.  The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection.  American Journal of Physiology: Gastrointestinal and Liver Physiology.  2008 Oct; 295(4):G664-70.
  • Heriazon A, Zhou P, Borojevic R, Foerster K, Streutker CJ, Ng T, Croitoru K. Regulatory T cells modulate staphylococcal enterotoxin B-induced effector T-cell activation and acceleration of colitis. Infect Immun. 2009 Feb;77(2):707-13. Epub 2008 Dec 8.
  • Stearns JC, Lynch MD, Senadheera DB, Tenenbaum HC, Goldberg MB, Cvitkovitch DG, Croitoru K, Moreno-Hagelsieb G, Neufeld JD. Bacterial biogeography of the human digestive tract. Scienctific Reports. 1:170, 2011.
  • Jones NL, Croitoru K, Vanner S, Soni R, Hope L. Research Topics in Gastrointestinal Disease: a report on the 10th meeting and an announcement of the 11th meeting. Canadian Journal of Gastroenterology. Aug;25(8):449-50, 2011.
  • Forster K, Goethel A, Chan CW, Zanello G, Streutker C, Croitoru K. An oral CD3-specific antibody suppresses T-cell-induced colitis and alters cytokine responses to T-cell activation in mice. Gastroenterology. Nov;143(5):1298-307, 2012.
  • Weizman AV, Ahn E, Thanabalan R, Leung W, Croitoru K, Silverberg MS, Steinhart AH, Nguyen GC. Characterisation of complementary and alternative medicine use and its impact on medication adherence in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics. Feb;35(3):342-9, 2012.
  • Leung W, Malhi G, Willey BM, McGeer AJ, Borgundvaag B, Thanabalan R, Gnanasuntharam P, Le B, Weizman AV, Croitoru K, Silverberg MS, Steinhart AH, Nguyen GC. Prevalence and predictors of MRSA, ESBL, and VRE colonization in the ambulatory IBD population. Journal of Crohns and Colitis. Aug;6(7):743-9, 2012.
  • Waterman M, Xu W, Dinani A, Steinhart AH, Croitoru K, Nguyen GC, McLeod RS, Greenberg GR, Cohen Z, Silverberg MS. Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease. Gut. Mar;62(3):387-94, 2013.

Tae Hart, PhD

Associate Scientific Staff

Tae HartDr. Tae Hart’s research centers on psychological factors associated with adjustment to illness in chronically-ill individuals and their spouses/partners. Primarily, Dr. Hart’s work has investigated quality of life, psychological distress, and symptom burden in patients who have been diagnosed with colorectal cancer.  Dr. Hart currently has a grant funded by the Canadian Institute of Health Research to examine physical and psychological health and quality of life in long-term survivors of colorectal cancer who are participants in the Ontario Familial Colorectal Cancer Registry.  Dr. Hart has expanded her program of research to examine the psychological impact of having Lynch syndrome and factors involved in managing risks associated with Lynch syndrome as well as other familial cancers (i.e., familial gastric cancer).


Centre
Mount Sinai Hospital
Zane Cohen Centre for Digestive Diseases

Contact
E-mail: zcc@mtsinai.on.ca

Publications

  • Hart, SL, Hoyt, MA, Diefenbach M, Anderson, DR, Kilbourn, KM, Craft, LL, Steel, JL, Cuijpers P, Mohr DC, Berendsen, M, Spring, B, Stanton AL. (2012). Meta-analysis of the efficacy of psychotherapeutic and pharmacologic interventions for depressive symptoms in adults diagnosed with cancer. Journal of the National Cancer Institute, 104(13), 990-1004.

  • Hart, SL, Charles, ST (2012). Negative affect and appraisals about cancer: Application of strength and vulnerability integration (SAVI). Health Psychology. [Epub ahead of print].

  • Kowalkowski, M.A., Hart, S.L., Du, X.L., Baraniuk, S., Latini, D.M. (2012). Cancer perceptions:  Implications from the 2007 Health Information National Trends Survey. Journal of Cancer Survivorship. DOI: 10.1007/s11764-012-0217y [Epub ahead of print].

  • Hart SL, Torbit, LA,  Crangle, CJ,  Esplen, MJ, Holter, S.,  Semotiok, K.,  Borgida, A.,  Ardiles, P.,  Rothenmund, H., & Gallinger, S. (2011). Moderators of cancer-related distress and worry after a pancreatic cancer genetic counselling and screening intervention.  Psycho-Oncology. doi: 10.1002/pon.2026. [Epub ahead of print]

  • Wang JY, Hart SL, Wilkowski KS, Lee JW, Delmotte EC, del Rosario KM, del Rosario AS, Varma MG. (2011). Gender-specific differences in pelvic organ function after proctectomy for inflammatory bowel disease. Diseases of the Colon and Rectum, 54, 66-76

Zane Cohen, M.D., F.R.C.S.(C)

Director - Zane Cohen Centre for Digestive Diseases (ZCC)
Colorectal Surgeon

Dr. Zane CohenZane Cohen obtained his MD degree in 1969 at the Faculty of Medicine, University of Toronto and following this he did his general surgical residency in the Gallie Program at the University of Toronto. During this time he spent two years doing transplantation immunological research with Dr. Rudy Falk, and following his general surgical training he spent two years in the United Kingdom. One clinical year was at St. Mark’s Hospital for Diseases of the Colon and Rectum, and another research year was done at the London Hospital in London, England in transplantation immunology.

Zane returned to join the staff of Department of Surgery at the University of Toronto and the Division of General Surgery at the Toronto General Hospital in 1977 as a Lecturer. Over the next 12 years he rose through the ranks to become a Professor of Surgery in the Department of Surgery at the University of Toronto.

In 1990 Zane Cohen moved to Mount Sinai Hospital to take up the position of Surgeon-in-Chief. He remained as Surgeon-In-Chief until June 30, 2006. In 1999, he was appointed as Chairman of the Division of General Surgery at the University of Toronto, an appointment which he now held until June 30, 2009. He has served as the Chairman of the Promotions Committee for the Department of Surgery from 1996 to 2001. He is an active member of the Senior Advisory Committee and the Finance Committee of the Department of Surgery.

Zane Cohen’s clinical interests have been almost entirely in the area of colon and rectal surgery. Zane had the opportunity to train with Professor Nils Kock on three separate occasions, and developed and brought to the university innovative surgical techniques which have helped thousands of patients afflicted with Inflammatory Bowel Disease and colorectal cancer. He has a specific interest in sphincter saving operations, and introduced the procedures of the Kock Pouch and the Pelvic Pouch techniques at the University of Toronto to patients with ulcerative colitis.

He also popularized the use of the double-staple technique for low anterior resections within the Division of General Surgery. Zane Cohen was the Co-Founder, along with Philip Gordon, of the Canadian Society of Colon and Rectal Surgeons and served as its second president. He was instrumental in developing a Colon and Rectal Training Program at the University of Toronto, amongst several of the teaching hospitals. His initial research interests were in the field of intestinal transplantation, and he, along with Dr. Bernard Langer, carried out the first human intestinal transplantation in the cyclosporine era.

Zane Cohen has authored over 230 manuscripts and book chapters, mainly in the area of Inflammatory Bowel Disease and colorectal cancer and intestinal transplantation. He has held peer reviewed research grants from all of the major granting agencies for his initial work in intestinal transplantation and his subsequent research work related to outcomes in inflammatory bowel disease. Zane has been an invited speaker world wide, he has an international reputation, and he is held in esteem by many of the general surgical residents, as well as the colorectal residents/fellows that he has trained.

He has been recognized for his achievements on many occasions, most recently by the Finkelstein Award for Continued Excellence in Research in Inflammatory Bowel Disease, the Mentors Award from the American Society of Colon and Rectal Surgeons in 2004, and the Colin R. Woolf Award for Excellence and Innovation in Course Coordination in 2005 for the General Surgery Update Course. He has been honored by Ben Gurion University of the Negev with a gala affair in Toronto attended by over 800 people.

Most recently, he has been again honoured with the naming of the Zane Cohen Centre for Digestive Diseases. Within this centre are 24 clinical researchers from medical students to surgical and medical trainees, as well as faculty, who are all involved in IBD and colon cancer research. The Dr. Zane Cohen lectureship has recently been initiated by a group of his colleagues.


Centre

Inflammatory Bowel Disease Group (IBD Group)
Familial Gastrointestinal Cancer Registry (FGICR)

Contact
E-mail: Zane.Cohen@SinaiHealthSystem.ca

Clinical Secretary
Rina Berardi
Phone: 416-586-4800 ext: 8346
Fax: 416-586-8644
E-mail: RinaBerardi@SinaiHealthSystem.ca

Office Location
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
451-600 University Avenue
Toronto, Ontario, Canada
M5G 1X5

Publications

  • Cosentino JS, Davies RJ, McLeod RS, Cohen Z. Lymphoma following ileal pouch anal anastomosis. Can J Surg. 2009 Aug;52(4):E123-E126.
  • Scarpa M, Victor CJ, O'Connor BI, Cohen Z, McLeod RS. Validation of an English version of the Padova quality of life instrument to assess quality of life following ileal pouch anal anastomosis. J Gastrointest Surg. 2009 Mar;13(3):416-22.
  • Mastracci TM, Cohen Z, Senagore A; Members of the Evidence Based Reviews in Surgery Group. Canadian Association of General Surgeons and American College of Surgeons Evidence-Based Reviews in Surgery. 24. Fast-track programs in colonic surgery. Systematic review of enhanced recovery programmes in colonic surgery. Can J Surg. 2008 Feb;51(1):70-2.
  • Davies RJ, O'Connor BI, Victor C, MacRae HM, Cohen Z, McLeod RS. A prospective evaluation of sexual function and quality of life after ileal pouch-anal anastomosis. Dis Colon Rectum. 2008 Jul;51(7):1032-5.
  • Raval MJ, Schnitzler M, O'Connor BI, Cohen Z, McLeod RS. Improved outcome due to increased experience and individualized management of leaks after ileal pouch-anal anastomosis. Ann Surg. 2007 Nov;246(5):763-70.
  • Fenech DS, Takahashi T, Liu M, Spencer L, Swallow CJ, Cohen Z, Macrae HM, McLeod RS. Function and quality of life after transanal excision of rectal polyps and cancers. Dis Colon Rectum. 2007 May;50(5):598-603.
  • Hendren SK, Swallow CJ, Smith A, Lipa JE, Cohen Z, MacRae HM, Gryfe R, O'Connor BI, McLeod RS. Complications and sexual function after vaginectomy for anorectal tumors. Dis Colon Rectum. 2007 Jun;50(6):810-6.

Kristine Laing

Physician Assistant

 

Centre
Mount Sinai Hospital
Department of Surgery

Contact
E-mail: zcc@mtsinai.on.ca

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