Diverse Ancestry Study in IBD

Details of Research

Contact: Joanne Stempak, Project Manager
Joanne.stempak@sinaihealth.ca

Primary Investigator: Mark Silverberg, MD
Enrolment: Ongoing

Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD in diverse ancestries

Eligibility:

IBD Subjects:

Self-identify as:

• Black, African, African American, Afro-Caribbean, Afro-Latino/a/x  or
• Hispanic/Latino/a/x  or
• Indigenous ancestry or
• Any other Black or Latin or Indigenous ancestry
• Available medical records to confirm IBD diagnosis (Crohn’s disease, Ulcerative colitis, IBD undetermined (IBD-U)) *medical release required for non-MSH patients
• Any age

Healthy Controls:

Self-identify as:

• Black, African, African American, Afro-Caribbean, Afro-Latino/a/x  or
• Hispanic/Latino/a/x  or
• Indigenous ancestry or
• Any other Black or Latin or Indigenous ancestry
• No personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
• Any age

Participation involves:

• One-time blood (preferred) or saliva sample
• Collection of clinical data

Background:

Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among diverse populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in these individuals.

For more information or to participate in this study, please email: IBD.research@sinaihealth.ca

Research Coordinators:
Jenny Lee, jenny.lee2@sinaihealth.ca