Etrolizumab in CD

Print

Details of Research

Contact: Shelley Mikolainis, Research Coordinator
416-586-4800 ext 4989
Shelley.Mikolainis@SinaiHealth.ca

Primary Investigator: Dr. Hillary Steinhart

Enrolment: Ongoing

Expectation: Cohort 1 will receive placebo, etrolizumab 105 mg SC Q4W (low dose), or etrolizumab 210 mg SC (high dose) 1:2:2 x 14-weeks, Cohort 2 will receive low-dose or high-dose regimens of etrolizumab. Cohort 3  will be randomized in a 2:3:3 ratio to receive placebo or etrolizumab low-dose or high-dose. Patients may be eligible for open-label treatment at week 14 of for entry into the Maintenance phase

Eligibility

  • intolerance, refractory disease or no response to at least one of: Corticosteroids, immunomodulators or anti-TNF therapy within past 5 years
  • Anti-TNF washout is 8 weeks prior to baseline
  • infection treated with IV or oral antibiotics within last 4 weeks


Exclusion
: draining fistula

WE INVITE YOU TO PARTNER WITH US TODAY
Donate to the Zane Cohen Centre
Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex. Copyright © 2021.
All Rights Reserved. A patient care, teaching and research centre affiliated with University of Toronto.
Powered by Joomla 1.7 Templates