IBD Research at the Zane Cohen Centre
Information on research and clinical trials in Inflammatory Bowel Disease
Current Studies
Crohn's Disease & Ulcerative Colitis
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Genetic Analysis of Infliximab-treated Inflammatory Bowel Disease Patients
Objective is to identify differentially expressed genes between responders and non-responders to Infliximab therapy and to examine if significant gene expression differences exist between Infliximab-treated Ulcerative colitis and Crohn’s Disease patients.
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The Identification of Genes for Inflammatory Bowel Disease
Objective is to identify new GENES that may be responsible for causing Inflammatory Bowel Disease (IBD) and understand the role of previously identified genes in IBD. -
The CCFC Michael J. Howorth GEM Project
To Identify why some individuals develop Crohn's Disease and others do not. This is accomplished by following healthy individuals considered to be at high risk for developing Crohn's disease over several years and measuring several factors before and after a diagnosis of Crohn's disease is made. -
The ENABLE Study (Equitability of Insurance Access to Biologics and its Impact on Effectiveness)
Objective is to formally assess the time interval from application for coverage of anti-TNF therapy (including Remicade and Humira) to first dose for privately vs. publicly insured patients with Inflammatory Bowel Disease (IBD) and to study whether potential delays in access to this therapy will have an effect on health outcomes such as hospitalization or surgery. -
Complementary and Alternative Medicine (CAM): Prevalence and Longitudinal Impact on Adherence to Conventional Therapy in Inflammatory Bowel Disease
Objective is to gain insight into the use complementary and alternative medicine (CAM) among patients with Inflammatory Bowel Disease (IBD), the different types of CAM, and perceived benefits of CAM that will help us better understand patients and potentially lead to better care. -
The SAFE Study (Survey on Awareness of Extraintestinal Inflammatory Bowel Disease)
Objective is to assess Inflammatory Bowel Disease patients' awareness of extra intestinal manifestations associated with Inflammatory Bowel Disease and inquire about where patients obtain their information on IBD.
Crohn's Disease
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Open label Humira (Adalimumab) Study in Crohn’s Disease
Objective is to study Humira in patients who have had Crohn’s disease for no longer than 4 years. -
Open label Remicade (Infliximab) Study in Crohn’s Disease
Objective is to study Remicade in patients with small bowel disease using wireless camera endoscopy. -
Crohn’s Disease Study involving an investigational oral medication (GSK1605786A). Double-blind, placebo-controlled study.
Objective is to study two doses of medication as compared to placebo. There is a maintenance and open-label study that follows this one. -
Crohn’s Disease Study involving an investigational subcutaneous medication (PF-04236921)). Double-blind, placebo-controlled study.
Objective is to study three doses of medication as compared to placebo. There is an open label study that follows this one. -
Mechanisms of Intestinal Inflammation Following Ileal Resection for Crohn's Disease
Objective is to evaluate microbial and gene expression factors which are associated with the recurrence of small bowel inflammation following surgery for Crohn’s Disease. This will have practical implications for evaluating which patients are more likely to rapidly recur as well as provide insight into the pathogenesis of Crohn’s Disease.



