Robin McLeod, M.D., F.R.C.S.(C)


Principal Investigator

Dr. Robin McLeodDr. Robin McLeod received a B.Sc. and MD from the University of Alberta. Following this, she completed training in General Surgery at the University of Toronto, Colorectal Surgery at the Cleveland Clinic, as well as training in clinical epidemiology at McMaster University before joining the faculty at the University of Toronto in 1985. She currently is a Fellow of the Royal College of Physicians and Surgeons of Canada, a Fellow of the American College of Surgeons, and a fellow ad hominem of the Royal College of Surgeons of Edinburgh. She is a Diplomate of the American Board of Surgery and the American Board of Colorectal Surgery.

Dr. McLeod is a Professor in the Departments of Surgery and Health Policy Management and Evaluation the University of Toronto. As well, she is the Surgical Lead of the Quality Improvement and Knowledge Transfer Program in the Surgical Oncology Program of Cancer Care Ontario.  She is a past president of the Canadian Association of General Surgeons and is currently a Regent of the American College of Surgeons. Dr. McLeod's clinical and research interests are colorectal cancer, IBD and evidence based medicine. She has led several multicentre Canadian clinical trials in colorectal surgery and has authored over 200 peer reviewed articles and 40 book chapters.

Dr. McLeod is the Chair of the Steering Committee for Evidence Based Reviews in Surgery, an internet journal club jointly sponsored by the Canadian Association of General Surgeons & American College of Surgeons. Dr. McLeod holds the Angelo and Alfredo De Gasperis Families Chair in Colorectal Cancer and IBD Research. As well, Dr. McLeod is the Vice Chair, Quality and Performance, in the Department of Surgery at the University of Toronto.


Inflammatory Bowel Disease Group (IBD Group)


  • Cosentino JS, Davies RJ, McLeod RS, Cohen Z. Lymphoma following ileal pouch anal anastomosis. Can J Surg. 2009 Aug;52(4):E123-E126.
  • Brace C, Schmocker S, Huang H, Victor JC, McLeod RS, Kennedy ED. Physicians' awareness and attitudes toward decision AIDS for patients with cancer. J Clin Oncol. 2010 May 1;28(13):2286-92.
  • Latosinsky S, Thirlby R, Urbach D, Baxter NN, Brasel KJ, Brown CJ, Chaudhury P, Cutter CS, Divino C, Dixon E, Dubois L, Fitzgerald GW, Henteleff HJ, Kirkpatrick AW, Latosinsky S, MacLean A, Mastracci TM, McLeod RS, Morris A, Neumayer LA, Temple LR, McKenzie ME; Members of the Evidence Based Reviews in Surgery Group. CAGS and ACS evidence based reviews in surgery. 32: Use of a surgical safety checklist to reduce morbidity and mortality. Can J Surg. 2010 Feb;53(1):64-6.
  • Smith AJ, Driman DK, Spithoff K, Hunter A, McLeod RS, Simunovic M, Langer B; Expert Panel on Colon and Rectal Cancer Surgery and Pathology. Guideline for optimization of colorectal cancer surgery and pathology.J Surg Oncol. 2010 Jan 1;101(1):5-12.
  • Spiegle G, Leon-Carlyle M, Schmocker S, Fruitman M, Milot L, Gagliardi AR, Smith AJ, McLeod RS, Kennedy ED. Development of a synoptic MRI report for primary rectal cancer.Implement Sci. 2009 Dec 2;4:79.
  • Forbes SS, O'Connor BI, Victor JC, Cohen Z, McLeod RS. Sepsis is a major predictor of failure after ileal pouch-anal anastomosis. Dis Colon Rectum. 2009 Dec;52(12):1975-81.
  • Eskicioglu C, Forbes SS, Aarts MA, Okrainec A, McLeod RS. Enhanced recovery after surgery (ERAS) programs for patients having colorectal surgery: a meta-analysis of randomized trials. J Gastrointest Surg. 2009 Dec;13(12):2321-9. Epub 2009 May 21.
  • Wright FC, Lookhong N, Urbach D, Davis D, McLeod RS, Gagliardi AR. Multidisciplinary cancer conferences: identifying opportunities to promote implementation. Ann Surg Oncol. 2009 Oct;16(10):2731-7. Epub 2009 Aug 7.
  • Forbes SS, Eskicioglu C, Nathens AB, Fenech DS, Laflamme C, McLean RF, McLeod RS; Best Practice in General Surgery Committee, University of Toronto. Evidence-based guidelines for prevention of perioperative hypothermia.J Am Coll Surg. 2009 Oct;209(4):492-503.e1. Epub 2009 Aug 20. Review.
  • Forbes SS, Eskicioglu C, McLeod RS, Okrainec A. Meta-analysis of randomized controlled trials comparing open and laparoscopic ventral and incisional hernia repair with mesh. Br J Surg. 2009 Aug;96(8):851-8. Review.
  • Cosentino JS, Davies RJ, McLeod RS, Cohen Z. Lymphoma following ileal pouch anal anastomosis.Can J Surg. 2009 Aug;52(4):E123-E126.
  • Devon KM, Vergara-Fernandez O, Victor JC, McLeod RS. Colorectal cancer surgery in elderly patients: presentation, treatment, and outcomes.Dis Colon Rectum. 2009 Jul;52(7):1272-7.
  • Wang L, Martin DD, Genter E, Wang J, McLeod RS, Small DM. Surface study of apoB1694-1880, a sequence that can anchor apoB to lipoproteins and make it nonexchangeable. J Lipid Res. 2009 Jul;50(7):1340-52. Epub 2009 Feb 26.
  • Joseph SV, Miller JR, McLeod RS, Jacques H. Effect of trans8, cis10+cis9, trans11 conjugated linoleic acid mixture on lipid metabolism in 3T3-L1 cells.Lipids. 2009 Jul;44(7):613-20. Epub 2009 May 22.
  • McLeod RS, Wolff BG, Ross S, Parkes R, McKenzie M; Investigators of the CAST Trial. Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial.Dis Colon Rectum. 2009 May;52(5):919-27.
  • Datta I, O'Connor B, Victor JC, Urbach DR, McLeod RS. Abdominal Surgery Impact Scale (ASIS) is responsive in assessing outcome following IPAA.J Gastrointest Surg. 2009 Apr;13(4):687-94. Epub 2009 Jan 16.
  • Scarpa M, Victor CJ, O'Connor BI, Cohen Z, McLeod RS. Validation of an English version of the Padova quality of life instrument to assess quality of life following ileal pouch anal anastomosis. J Gastrointest Surg. 2009 Mar;13(3):416-22. Epub 2008 Dec 17.
  • Devon KM, Brown CJ, Burnstein M, McLeod RS. Cancer of the anus complicating perianal Crohn's disease.Dis Colon Rectum. 2009 Feb;52(2):211-6.
  • Devon KM, McLeod RS. Pre and peri-operative erythropoietin for reducing allogeneic blood transfusions in colorectal cancer surgery. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007148. Review.
  • Gagliardi AR, Wright FC, Davis D, McLeod RS, Urbach DR. Challenges in multidisciplinary cancer care among general surgeons in Canada.BMC Med Inform Decis Mak. 2008 Dec 22;8:59.
  • McLeod RS. Ileal pouch anal anastomosis: pregnancy--before, during and after. J Gastrointest Surg. 2008 Dec;12(12):2150-2. Epub 2008 Oct 10.
  • Cooper MH, Miller JR, Mitchell PL, Currie DL, McLeod RS. Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE-/- mice fed a high-cholesterol diet. Atherosclerosis. 2008 Oct;200(2):294-302. Epub 2008 Feb 15.
  • Fisher EA, Lapierre LR, Junkins RD, McLeod RS. The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway.J Lipid Res. 2008 Oct;49(10):2149-60. Epub 2008 Jun 11.
  • Mitchell PL, McLeod RS. Conjugated linoleic acid and atherosclerosis: studies in animal models. Biochem Cell Biol. 2008 Aug;86(4):293-301. Review.
  • Davies RJ, O'Connor BI, Victor C, MacRae HM, Cohen Z, McLeod RS. A prospective evaluation of sexual function and quality of life after ileal pouch-anal anastomosis. Dis Colon Rectum. 2008 Jul;51(7):1032-5. Epub 2008 May 3.
  • Brown CJ, Fenech DS, McLeod RS. Reconstructive techniques after rectal resection for rectal cancer.Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006040. Review.
  • Miller JR, Siripurkpong P, Hawes J, Majdalawieh A, Ro HS, McLeod RS. The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms.J Lipid Res. 2008 Mar;49(3):550-62. Epub 2007 Dec 4.
  • Brown CJ, Jaffer H, Jaffer N, Burul C, McLeod RS. Spinal epidural abscess -- a rare complication of inflammatory bowel disease.Can J Gastroenterol. 2008 Feb;22(2):177-80.
  • Kennedy ED, To T, Steinhart AH, Detsky A, Llewellyn-Thomas HA, McLeod RS. Do patients consider postoperative maintenance therapy for Crohn's disease worthwhile? Inflamm Bowel Dis. 2008 Feb;14(2):224-35.
  • Aarts MA, Hancock JN, Heyland D, McLeod RS, Marshall JC. Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials. Crit Care Med. 2008 Jan;36(1):108-17. Review.
  • Lad SV, Haider MA, Brown CJ, Mcleod RS. MRI appearance of perianal carcinoma in Crohn's disease.J Magn Reson Imaging. 2007 Dec;26(6):1659-62.
  • Raval MJ, Schnitzler M, O'Connor BI, Cohen Z, McLeod RS. Improved outcome due to increased experience and individualized management of leaks after ileal pouch-anal anastomosis.Ann Surg. 2007 Nov;246(5):763-70.
  • McLeod RS. Evidence-Based Reviews in Surgery to begin its seventh year.Bull Am Coll Surg. 2007 Nov;92(11):26-7. No abstract available.
  • McLeod RS. Comparison of data extraction from standardized versus traditional narrative operative reports for database related research and quality control.
    Surgery. 2007 Sep;142(3):420-1.
  • Burnett JR, Zhong S, Jiang ZG, Hooper AJ, Fisher EA, McLeod RS, Zhao Y, Barrett PH, Hegele RA, van Bockxmeer FM, Zhang H, Vance DE, McKnight CJ, Yao Z. Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem. 2007 Aug 17;282(33):24270-83. Epub 2007 Jun 22.
  • McLeod RS. Instilling a culture of evidence-based surgery in Canada.World J Surg. 2007 Aug;31(8):1551-5.
  • Hendren SK, Swallow CJ, Smith A, Lipa JE, Cohen Z, MacRae HM, Gryfe R, O'Connor BI, McLeod RS. Complications and sexual function after vaginectomy for anorectal tumors.Dis Colon Rectum. 2007 Jun;50(6):810-6.
  • Fenech DS, Takahashi T, Liu M, Spencer L, Swallow CJ, Cohen Z, Macrae HM, McLeod RS. Function and quality of life after transanal excision of rectal polyps and cancers. Dis Colon Rectum. 2007 May;50(5):598-603.
  • Brown CJ, Dubreuil D, Santoro L, Liu M, O'Connor BI, McLeod RS. Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. Dis Colon Rectum. 2007 Apr;50(4):442-8.
  • Barkun J, Woo D, Marcaccio M, Soper N, McLeod RS; Members of the Evidence Based Reviews in Surgery Group. Canadian Association of General Surgeons and American College of Surgeons evidence based reviews in surgery. 20. Small gallstones may increase the risk of pancreatitis; is there a benefit for a prophylactic cholecystecomy? Can J Surg. 2007 Feb;50(1):62-5.
  • Ro HS, Zhang L, Majdalawieh A, Kim SW, Wu X, Lyons PJ, Webber C, Ma H, Reidy SP, Boudreau A, Miller JR, Mitchell P, McLeod RS. Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis.Obesity (Silver Spring). 2007 Feb;15(2):288-302
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