Robert Gryfe, MD, PhD


Colorectal Surgical Oncologist

Dr. Robert GryfeRobert Gryfe MD, PhD, is a colorectal surgical oncologist at Mount Sinai Hospital and researcher at Mount Sinai’s Samuel Lunenfeld Research Institute. Dr. Gryfe’s clinical practice specializes in patients with hereditary cancer syndromes and the surgical management of patients with colon and rectal cancer. His research laboratory investigates the genetic determinants of colorectal cancer risk, prognosis and response to chemotherapy.

Colon & Rectal Surgery and Cancer Molecular Genetics

Phone: 416-586-5088
Fax: 416-586-1586

Office Location
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
455-600 University Avenue
Toronto, ON M5G 1X5


  • Gryfe R. Overview of colorectal cancer genetics. Surg Oncol Clin N Am. 2009 Oct;18(4):573-83. Review.
  • Wirtzfeld DA, Mikula L, Gryfe R, Ravani P, Dicks EL, Parfrey P, Gallinger S, Pollett WG. Concordance with clinical practice guidelines for adjuvant chemotherapy in patients with stage I-III colon cancer: experience in 2 Canadian provinces. Can J Surg. 2009 Apr;52(2):92-7.
  • Cleary SP, Kim H, Croitoru ME, Redston M, Knight JA, Gallinger S, Gryfe R. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum. 2008 Oct;51(10):1467-73; discussion 1473-4. Epub 2008 Jul 10.
  • Hendren SK, Swallow CJ, Smith A, Lipa JE, Cohen Z, MacRae HM, Gryfe R, O'Connor BI, McLeod RS. Complications and sexual function after vaginectomy for anorectal tumors. Dis Colon Rectum. 2007 Jun;50(6):810-6.
  • Labbé E, Lock L, Letamendia A, Gorska AE, Gryfe R, Gallinger S, Moses HL, Attisano L. Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res. 2007 Jan 1;67(1):75-84.