Physicians of the Zane Cohen Centre

Advanced Fellowships in Inflammatory Bowel Disease (IBD) at Mount Sinai Hospital

The Advanced Fellowship in Inflammatory Bowel Disease is a one year, funded position which will provide the applicant with focused training in clinical care and clinical/translational or basic research in Inflammatory Bowel Disease. The Fellowship will be based primarily at Mount Sinai Hospital in Toronto, Canada.

The program will be designed according to the interests of the successful applicant, with the approval of the Faculty. The intent of the Fellowship is to position the trainee for a fulltime academic appointment by providing the skills necessary to achieve a university faculty position if desired. It would also be useful for a community practice position with a strong interest in the clinical care of IBD patients.

To learn more about the Advanced Fellowship in Inflammatory Bowel Disease and how to apply, download the brochure (1 mb pdf pdf.gif)

Publications in IBD

The following are recent publications (1997 or later) from members of the Inflammatory Bowel Disease Group at Mount Sinai Hospital.

2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997

2007

Dassopoulos T, Nguyen GC, Bitton A, Bromfield GP, Schumm LP, Wu Y, Elkadri A, Regueiro M, Siemanowski B, Torres EA, Gregory FJ, Kane SV, Harrell LE, Franchimont D, Achkar JP, Griffiths A, Brant SR, Rioux JD, Taylor KD, Duerr RH, Silverberg MS, Cho JH, Steinhart AH. Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC). Inflammatory Bowel Diseases 2007; 13(8):975-983.

De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD; Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes Immun. 2007 Jul;8(5):387-97. Epub 2007 May 31.

Elkadri A, Lal S, Stempak JM, Walters T, Griffiths AM, Greenberg GR, Steinhart AH, Silverberg MS. Increasing prevalence of serological markers predicts aggressive Crohn’s disease behaviour. Gastroenterology 2007; 132 (4): A362.

Hugot JP, Zaccaria I, Cavanaugh J, Yang H, Vermeire S, Lappalainen M, Schreiber S, Annese V, Jewell DP, Fowler EV, Brant SR, Silverberg MS, Cho J, Rioux JD, Satsangi J, Parkes M for the IBD International Genetics Consortium. Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. American Journal of Gastroenterology 2007; 102(6):1259-1267.

Kennedy ED, To T, Steinhart AH, Detsky A, Llewellyn-Thomas HA, McLeod RS. Do patients consider postoperative maintenance therapy for Crohn's disease worthwhile? Inflamm Bowel Dis. 2007 Oct 11; [Epub ahead of print]

Lal S, Steinhart AH. Infliximab for ulcerative colitis following liver transplantation. Eur J Gastroenterol Hepatol 2007; 19:277-280.

Lal S, Steinhart AH. Diphyllobothrium latum: a case of an incidental finding. World J Gastroenterol. 2007 Mar 28;13(12):1875-6.

Lal S, Appelton J, Mascarenhas J, Stempak JM, Esplen MJ, Silverberg MS. Attitudes toward genetic testing in patients with inflammatory bowel disease. European Journal of Gastroenterology and Hepatology 2007; 19(4):321-327.

Maunder RG, Greenberg GR, Lancee WJ, Steinhart AH, Silverberg MS. The impact of ulcerative colitis is greater in unmarried and young patients. Can J Gastroenterol. 2007 Nov;21(11):715-20.

Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM, Silverberg MS, Rotin D. Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. Current Biology 2007; 17(14):1212-1218.

Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR. Genome-wide association study identifies five susceptibility loci for Crohn's disease and implicates a role for autophagy in disease pathogenesis. Nature Genetics 2007; 39: 596-604. [Epub 2007 Apr 15]

Silverberg MS, Duerr RH, Brant SR, Bromfield G, Datta LW, Jani N, Kane SV, Rotter JI, Schumm LP, Steinhart AH, Taylor KD, Yang H, Cho JH, Rioux JD, Daly MJ for the NIDDK IBD Genetics Consortium. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn’s disease. European Journal of Human Genetics 2007; 15(3):328-335.

Steinhart AH, Forbes A, Mills EC, Rodgers-Gray BS, Travis SP. Systematic review: the potential influence of mesalazine formulation on maintenance of remission in Crohn's disease. Aliment Pharmacol Ther. 2007 Jun 15;25(12):1389-99.

Turner D, Steinhart AH, Griffiths AM. Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews 2007 Issue 3. Art. No. CD006443; DOI: 10.1002/14651858.CD006443.pub2.

Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, Uusoue K, Walters TD, Zachos M, Mamula P, Beaton DE, Steinhart AH, Griffiths AM. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology. 2007 Aug;133(2):423-32. Epub 2007 May 21.

Turner D, Walsh CM, Benchimol EI, Mann EH, Thomas KE, Chow C, McLernon RA, Walters TD, Steinhart AH, Griffiths AM. Severe paediatric ulcerative colitis: incidence, outcomes, and optimal timing for second line therapy. Gut. 2007 Nov 2; [Epub ahead of print]

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2006

Achkar JP, Dassopoulos T, Silverberg MS, Tuvlin JA, Duerr RH, Brant SR, Siminovitch K, Reddy D, Datta LW, Bayless TM, Zhang L, Barmada MM, Rioux JD, Steinhart AH, McLeod RS, Griffiths AM, Cohen Z, Yang H, Bromfield GP, Schumm P, Hanauer SB, Cho JH, Nicolae DL. Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. American Journal of Gastroenterology 2006; 101(3): 572-580.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identified IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3. [e-published Science Express 10/26/2006]

Lal S, Stempak JM, Elkadri AA, Law C, Walters TD, Griffiths AM, Greenberg GR, Steinhart AH, Silverberg MS. Novel association between the C3435T polymorphism of the MDR1 gene and Crohn’s disease. Gastroenterology 2006; 130(4): A5584.

Lal S, Stempak JM, Law C, Elkadri AA, Steinhart AH, Silverberg MS. Association between the C3435T polymorphism of the MDR1 gene and Crohn’s disease. Inflamm Bowel Dis 2006;12:1006-7.

Lal S, Steinhart AH. Antibiotic therapy for Crohn’s disease. Can J Gastroenterol 2006;20:651-5.

Maser EA, Villella R, Silverberg MS, Greenberg GR. Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease. Clinical Gastroenterology and Hepatology 2006; 4:1248-1254.

Maunder RG, Lancee WJ, Hunter JJ, Greenberg GR, Steinhart AH. Attachment insecurity moderates the relationship between disease activity and depressive symptoms in ulcerative colitis. Inflamm Bowel Dis 2005;11(10):919-26

Maunder RG, Greenberg GR, Nolan RP, Lancee WJ, Steinhart AH, Hunter JJ. Pattern of autonomic response to acute stress predicts disease activity in ulcerative colitis. Eur J Gastroenterol Hepatol 2006;18:413-20.

Maunder RG, Greenberg GR, Hunter JJ, Lancee WJ, Steinhart AH, Silverberg MS. Psychobiological subtypes of ulcerative colitis: pANCA status moderates the relationship between disease activity and psychological distress. American Journal of Gastroenterology 2006; 101(11):2546-2551.

Nguyen GC, Torres EA, Regueiro M, Bromfield G, Bitton A, Stempak J, Dassopoulos T, Schumm P, Gregory FJ, Griffiths AM, Hanauer SB, Hanson J, Harris ML, Kane SV, Orkwis HK, Lahaie R, Oliva-Hemker M, Pare P, Wild GE, Rioux JD, Yang H, Duerr RH, Cho JH, Steinhart AH, Brant SR, Silverberg MS. Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort. Am J Gastroenterol. 2006 May;101(5):1012-23.

Regueiro M, Loftus EV, Steinhart AH, Cohen RD. Medical management of left-sided ulcerative colitis and proctitis. Critical evaluation of therapeutic trials. Inflamm Bowel Dis 2006;12: 979-994.

Regueiro M, Loftus EV, Steinhart AH, Cohen RD. Clinical guidelines for the medical management of left-sided ulcerative colitis and proctitis. Summary statement. Inflamm Bowel Dis 2006; 12: 972-978.

Satsangi J, Silverberg MS, Vermeire S, Colombel JF. Leading Article: The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006; 55: 749-753.

Silverberg MS. OCTNs: Will the real IBD5 gene please stand up. World Journal of Gastroenterology 2006; 12 (23): 3678-3681.

Turner D, Walsh C, Steinhart AH, Griffiths AM. Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and meta-regression. Clin Gastroenterol Hepatol 2007; 5: 103-110 [epub 2006 Dec 8].

Van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JB, Annese V, Latiano A, Silverberg MS, Bitton A, Fisher SA, Steinhart AH, Forbes A, Sanderson J, Prescott NJ, Strachan DP, Playford RJ, Mathew CG, Wijmenga C, Daly MJ, Rioux JD, Van Heel DA. Genetic Variation in Myosin IXB Is Associated With Ulcerative Colitis. Gastroenterology. 2006;131:1768-74.[Epub 2006 Sept 8]

Walters TD, Silverberg MS. Genetics of inflammatory bowel disease: current status and future directions. Canadian Journal of Gastroenterology 2006; 20(10): 633-639.

Xue S, Stempak JM, Elkadri AA, Greenberg GR, Walters TD, Griffiths AM, Steinhart AH, Silverberg MS. Serological markers are associated with severity of disease and need of surgery in IBD patients. Gastroenterology 2006; 130(4): A197.

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2005

Feagan BG, Greenberg GR, Wild G, Fedorak RN, Pare P, McDonald JWD, Dube R, Cohen A, Steinhart AH, Landau S, Aguzzi RA, Fox IH, Vandervoort MK. Treatment of ulcerative colitis with a humanized antibody to the alpha-4 beta-7 integrin. N Engl J Med 2005; 352:2499-507.

Marcelletti J, Moskovitz D, Stempak J, Steinhart AH, Greenberg GR, Cohen Z, McLeod RS, Simpson L, Smith K, Wang S, Carroll S, Silverberg MS. Anti-microbial antibody markers as prognostic indicators of inflammatory bowel disease course. Gastroenterology 2005; 128(4): A305.

Otley A, Steinhart AH. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2005: CD000296. Review.

Pierik M, Yang H, Barmada MM, Cavanaugh JA, Annese V, Brant SR, Cho JH, Duerr RH, Hugot JP, McGovern DP, Paavola-Sakki P, Radford-Smith GL, Pavli P, Silverberg MS, Schreiber S, Taylor KD, Vlietinck R and the IBD International Genetics Consortium. The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. Inflammatory Bowel Diseases 2005;11(1): 1-7.

Sands BE, Abreu MT, Ferry GD, Griffiths AM, Hanauer SB, Isaacs KL, Lewis JD, Sandborn WJ, Steinhart AH. Design Issues and Outcomes in IBD Clinical Trials. Inflamm Bowel Dis 2005;11:S22-8.

Siffledeen JS, Fedorak RN, Siminoski K, Jen H, Vaudan E, Abraham N, Steinhart H, Greenberg G. Randomized trial of etidronate plus calcium and vitamin D for treatment of low bone mineral density in Crohn’s disease. Clin Gastroenterol Hepatol 2005;3:122-32.

Silverberg MS, Brant SR, Torres E, Regueiro M, Achkar JP, Duerr RH, Cho JH, Rioux JD, Bromfield FP, Yang H, Steinhart AH. Characterization of a large repository for the study of inflammatory bowel disease genetics. Gastroenterology 2005; 128(4): A137.

Silverberg MS, Cho JH, Duerr RH, Bromfield GP, Brant SR, Yang H, Rioux JD, Daly MJ. Association of the IBD5 locus with inflammatory bowel disease in a very large North American population. Gastroenterology 2005; 128(4): A137.

Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus Jr EV, Pena AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Canadian Journal of Gastroenterology 2005; 19 Suppl A:5-36.

Silverberg MS. The time has come for NOD2/CARD15 testing for families with Crohn's disease: pro. Inflammatory Bowel Diseases 2005; 11(5): 504-506.

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2004

Appelton JI, Mascarenhas J, Esplen MJ, Butler K, Rubin DT, Silverberg MS. Demand for genetic testing for inflammatory bowel disease. Gastroenterology 2004; 126(4):A352.

Karban AS, Okzaki T, Panhuysen CIM, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Human Molecular Genetics 2004;13(1):35-45.

Kennedy ED, Urbach DR, Krahn MD, Steinhart AH, Cohen Z, McLeod RS. Azathioprine or ileocolic resection for steroid-dependent terminal ileal Crohn's disease? A Markov analysis. Dis Colon Rectum 2004;47:2120-30.

Mow WS, Landers CJ, Steinhart AH, Feagan BG, Croitoru K, Seidman E, Greenberg GR, Targan SR. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn’s disease: a pilot study. Dig Dis Sci. 2004 Aug; 49(7-8):1280-6.

Newman B, Silverberg MS, Gu X, Zhang Q, Lazaro A, Steinhart AH, Greenberg GR, Griffiths AM, McLeod RS, Cohen Z, Fernandez-Vina M, Amos CI, Siminovitch K. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. American Journal of Gastroenterology 2004; 99(2): 306-315.

Panaccione R, Fedorak RN, Aumais G, Bernstein CN, Bitton A, Croitoru K, Enns R, Feagan B, Fishman M, Greenberg G, Griffiths A, Marshall JK, Rasul I, Sadowski D, Seidman E, Steinhart H, Sutherland L, Walli E, Wild G, Williams CN, Zachos M; Canadian Association of Gastroenterology. Canadian Association of Gastroenterology Clinical Practice Guidelines: the use of infliximab in Crohn’s disease. Can J Gastroenterol. 2004 Aug;18(8):503-8.

Siffledeen JS, Fedorak RN, Siminoski K, Jen H, Vaudan E, Abraham N, Steinhart H, Greenberg G. Bones and Crohn’s: risk factors associated with low bone mineral density in patients with Crohn’s disease. Inflamm Bowel Dis 2004 May;10(3):220-8.

Steinhart AH. Commentary: Bone density in women with inflammatory bowel disease. Can J Gastroenterol. 2004 Mar;18(3):183-4.

van Heel DA, Fisher SA, Kirby A, Daly MJ, Rioux JD, Lewis CM and the Genome Scan Meta-Analysis Group of the IBD International Genetics Consortium (Silverberg MS, contributing author). Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Human Molecular Genetics 2004;13 (7): 763-770.

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2003

Aghdassi E, Wendland BE, Steinhart AH, Wolman SL, Jeejeebhoy K, Allard JP. Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial. Am J Gastroenterol. 2003 Feb;98:348-53.

Evans JP, Steinhart AH, Cohen Z, McLeod RS. Home total parenteral nutrition: an alternative to early surgery for complicated inflammatory bowel disease. J Gastrointest Surg. 2003 May-Jun;7(4):562-6.

Griffiths AM, Sherman P, Thijs G, Ray P, Silverberg MS. Prevalence of NOD2/CARD15 mutations in pediatric IBD. Gastroenterology 2003; 124(4):A367.

Nikolaus S, Rutgeerts P, Fedorak R, Steinhart AH, Wild GE, Theuer D, Mohrle J, Schreiber S. Interferon beta-1a in ulcerative colitis: a placebo-controlled, randomised, dose escalating study. Gut. 2003 Sep;52(9):1286-90. Erratum in: Gut. 2003 Nov;52(11)1657.

Siffledeen JS, Siminoski K, Steinhart H, Greenberg G, Fedorak RN. The frequency of vitamin D deficiency in adults with Crohn’s disease. Can J Gastroenterol 2003 Aug;17(8):473-8.

Silverberg MS, Berk T, Riddell R, Gallinger S. Significance of fundic gland polyp carpeting in familial adenomatous polyposis. Gastroenterology 2003; 124(4):A549.

Silverberg MS, Mirea L, Bull SB, Murphy JE, Steinhart AH, Greenberg GR, McLeod RS, Cohen Z, Wade JA, Siminovitch KA. A population and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease. Inflammatory Bowel Diseases 2003;9(1):1-9.

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2002

Bernstein CN, Eaden J, Steinhart AH, Munkholm P, Gordon PH. Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid. Inflamm Bowel Dis. 2002 Sep;8(5):356-61. Review.

Habtezion A, Silverberg MS, Parkes R, Mikolainis S, Steinhart AH. Risk factors for low bone density in Crohn’s disease. Inflamm Bowel Dis. 2002 Mar;8(2):87-92.

Mirea L, Bull SB, Silverberg MS, Siminovitch KA. Case study in data analysis: The genetic analysis of inflammatory bowel disease. The Canadian Journal of Statistics 2002; 30(1): 137-145.

Moskovitz D, Steinhart H, Amre D, McLeod R, Siminovitch K, Cohen Z, Greenberg G, Seidman E, Silverberg MS. Prevalence of serological markers in familial inflammatory bowel disease. Gastroenterology 2002;122(4):A176.

Silverberg MS, Mirea L, Bull SB, Murphy JE, Steinhart H, Greenberg GR, McLeod RS, Cohen Z, Wade JA, Siminovitch KA. A population and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease. Gastroenterology 2002;122(4):A299.

Steinhart AH, Feagan BG, Greenberg GR, Wong CJ, Vandervoort M, Mikolainis S, Croitoru K, Seidman E, Leddin DJ, Bitton A, Drouin E, Cohen A, Greenberg GR. Combined budesonide and antibiotic therapy for active Crohn’s disease: a randomized controlled trial. Gastroenterology. 2002 Jul;123(1):33-40.

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2001

de Rooy E.C., Toner B.B., Maunder, R.G., Greenberg G.R., Baron D., Steinhart A.H., McLeod R., Cohen Z., Concerns of patients with inflammatory bowel disease: results from a clinical population. Am J Gastroenterol, 96 (6), 2001, 1816-1821.

Feagan BG, Steinhart AH, Wild G, Fedorak F, Pare P, Enns R, Panaccione R. Infliximab in the treatment of Crohn's disease: efficacy, safety, and pharmacoeconomics. Canadian Journal of Pharmacology, (8)4 2001, 188-198

Hunter J., Maunder R.G. Using attachment theory to understand illness behavior. General Hospital Psychiatry, (4), 2001, 177-182.

Maunder R.G., Hunter J.J., Attachment and psychosomatic medicine: Developmental contributions to stress and disease. Psychosom Med, 63 (4), 2001, 556-567.

Maunder R., Esplen MJ Supportive-expressive group psychotherapy for inflammatory bowel disease. Canadian Journal of Psychiatry, (7), September 2001, 622-626.

Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart AH, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, Stone V, Chow C, Cohen A, Langelier D, Lapointe G, Gaudet D, FaithJ, Branco N, Bull SB, McLeod RS, Griffiths AM, Bitton A, Greenberg GR, LanderES, Siminovitch KA, Hudson TJ. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature Genetics. 2001 Oct; 29(2):223-8.

Silverberg MS, Boright A, Siminovitch KA. Positional cloning and disease gene identification. In: Kalow W, Meyer UA, Tyndale R, eds. Pharmacogenomics. New York: Marcel Dekker, 2001, pp 363-387.

Silverberg MS, Clelland C, Murphy JE, Steinhart AH, McLeod RS, Greenberg GR,Cohen Z, Siminovitch KA. Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin. Human Genetics. 2001 Mar;108(3):205-10.

Silverberg MS, Moskovitz DN, Daly MJ, Rioux JD, McLeod RS, Greenberg GR, Cohen Z, Hudson TJ, Siminovitch KA. Steinhart AH. Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies. Gut 2001;6:773-776.

Simms L, Steinhart AH. Budesonide for maintenance of remission in Crohn's disease (Cochrane Review). Cochrane Database System Rev. 2001;1:CD002913.

Steinhart AH. Clinical perspectives – biologics in IBD: What’s all the fuss? Can J Gastroenterol. 2001 Dec;15(12):799-804.

Wendland BE, Aghdassi E, Tam C, Carrrier J, Steinhart AH, Wolman SL, Baron D,Allard JP. Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. American Journal of Clinical Nutrition. 2001 Aug;74(2):259-64.

The IBD International Genetics Consortium (Silverberg MS, one of the authors). International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled dataset: Crohn's disease and chromosome 16. American Journal of Human Genetics 2001;68:1165-1171.

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2000

Casati, J., Toner, B.B., de Rooy, E., Drossman, D., Maunder, R. Concerns of patients with inflammatory bowel disease: A review of emerging themes. Dig Dis Sci, 45 (1), 2000, 26-31.

Feagan BG, Fedorak RN, Irvine EJ, Wild G, Sutherland L, Steinhart AH, Greenberg GR, Koval J, Wong CJ, Hopkins M, Hanauer SB, McDonald JWD. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. New England Journal of Medicine 2000;342:1627-32

Kennedy ED, Detsky AS, Llewellyn-Thomas HA, O'Connor BI, Varkul M, Steinhart AH, Cohen Z, McLeod RS. Can the standard gamble be used to determine utilities for uncertain health states? An example using post-operative maintenance therapy in Crohn's disease. Medical Decision Making 2000; 20:72-78.

MacRae HM, Regehr G, Leadbetter W, Reznick RK: A Comprehensive Assessment of Senior Surgical Residents. American Journal of Surgery 2000: 179-3: pp 190-3.

Maunder R.G., Mediators of stress effects in inflammatory bowel disease: Not the usual suspects, Journal of Psychosomatic Research, 48, 2000, 569-77.

Maunder R., Lancee, W., Greenberg, G., Hunter, J., Fernandes, B. Insecure attachment in a subgroup of ulcerative colitis defined by ANCA status. Dig Dis Sci, 45, 2000, 2127-2132.

Maunder, R. Psychotherapy for inflammatory bowel disease: New prospects, in Trends in Inflammatory Bowel Disease Therapy 1999, C.N. Williams, R.F. Bursey, D.G. Gall et al. (eds.) Kluwer Academic Publishers, Boston, 2000.

Moskovitz, D.N., Maunder R.G., Cohen, Z., McLeod, R.S., MacRae, H. Coping behavior and social support contribute independently to higher quality of life after surgery for inflammatory bowel disease. Dis Colon Rectum, 43 (4), 2000, 517-21.

Moskovitz DN, Maunder RG, Cohen Z, mcLeod RS, MacRae H: Use of community resources before inflammatory bowel disease surgery is associated with postsurgical quality of life. Canadian Journal of Gastroenterology 2000: 14(2): pp 95-8.

Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Grettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA. Genome-wide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. American Journal of Human Genetics 2000;66:1863-1870.

Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. American Journal of Human Genetics 2000; 66:1863-1870.

Silverberg MS, Daly MJ, Rioux JD, McLeod RS, Greenberg GR, Cohen Z, Lander ES, Hudson T, Siminovitch KA, Steinhart AH. Effect of diagnostic misclassification on the ability to detect linkage in inflammatory bowel disease. Gastroenterology 2000;118(4):A337.

Silverberg MS, Somani AK, Siminovitch KA. Genetics of inflammatory bowel disease: where are we? In: Williams CN, Bursey RF, Gall DG, Martin F, McLeod RS, Sutherland LR, Wallace JL, eds. Trends in Inflammatory Bowel Disease Therapy 1999. Dordrecht, The Netherlands: Kluwer Academic Publishers, 2000:3-12.

Silverberg MS, Steinhart AH. Bone density in inflammatory bowel disease. Clinical Perspectives in Gastroenterology 2000;3(3):117-124.

Silverberg MS, Steinhart AH, Siminovitch KA, Cole DEC, Rubin LA, Greenberg GR. Genetic and environmental factors associated with diminished bone mineral density differ in ulcerative colitis and Crohn’s disease. Gastroenterology 2001;120(5):A457.

Steinhart AH. Maintenance therapy in Crohn's disease. Canadian Journal of Gastroenterology. 2000 Sep;14 Suppl C:23C-28C.

Steinhart AH. Topic: Clinical Perspective - Biologics in IBD: What's all the fuss? Canadian Journal of Gastroenterology 2000 (In press).

Steinhart AH. Use of corticosteroids in inflammatory bowel disease: Canadian Association of Gastroenterology Practice Guidelines. Canadian Journal of Gastroenterology 2000 (in press).

Szalay D, Macrae H, Regher G, Reznick R: Using operative outcome to assess technical skill. American Journal of Surgery 2000: 180(3): pp 234-7.

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1999

MacRae HM, McLeod RS: Treatment of the persistent rectovaginal fistula. In: Seminars in Colon and Rectal Surgery (David J Schoetz, Jr, MD, eds). WB Saunders Company, Orlando, Florida 1999: pp 49-55.

Maunder R., Toner, B., de Rooy,. E., Moskovitz, D. The influence of sex and disease on illness-related concerns in inflammatory bowel disease. Canadian Journal of Gastroenterology, 13, 1999, 728-32.

Silverberg MS, Steinhart AH, McLeod RS, Griffiths A, Mirea L, Bull SB, Greenberg GR, Cohen Z, Rioux JD, Daly MJ, Green T, Stone V, Hudson T, Lander ES, Siminovitch KA. Evidence for linkage between Crohn’s disease and a locus near the MHC on chromosome 6 in a Canadian IBD population. Gastroenterology 1999;116(4):A820.

Silverberg MS, Taylor CL, Murphy J, Steinhart AH, Cohen Z, Greenberg GR, McLeod RS, Siminovitch KA. Contribution of the APCI1307K mutation to colorectal cancer susceptibility in IBD patients of Ashkenazi Jewish origin. Gastroenterology 1999;116(4):A504.

Silverberg MS, Murphy J, Steinhart AH, McLeod RS, Griffiths A, Mirea L, Bull SB, Greenberg GR, Cohen Z, Wade JA, Siminovitch KA. The HLA DRB1*0103 allele is associated with Crohn’s disease in a Toronto inflammatory bowel disease population. Gastroenterology 1999;116(4):A820.

Steinhart AH, Ewe K, Griffiths AM, Modigliani R, Thomsen OO. Corticosteroids for maintaining remission of Crohn's disease (Cochrane Review). In: The Cochrane Library, Issue 1, 1999. Oxford: Update Software.

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1998

Greenbloom SL, Steinhart AH, Greenberg GR. Combination ciprofloxacin and metronidazole for active Crohn's disease. Canadian Journal of Gastroenterology 1998;12:53-56.

Kennedy ED, Blair JE, Ready R, Wolff BG, Steinhart AH, Carryer PW, McLeod RS. Patients' perceptions of their participation in a clinical trial for postoperative Crohn's disease. Canadian Journal of Gastroenterology 1998; 12: 287-291.

MacRae HM, McLeod RS: Handsewn versus stapled anastomoses in colon and rectal surgery: A meta-analysis. Diseases of the Colon and Rectum 1998.

Regehr G, MacRae HM, Reznick G, Szalay D: Comparing the psychometric properties of checklists and global rating scales for assessing performance in an OSCE-format examination. Academic Medicine 1998: 73: pp 993-997.

Rioux JD, Daly MJ, Green T, Stone V, Lander ES, Hudson TJ and Steinhart AH, Bull SB, Cohen Z, Greenberg GR, Griffiths A, McLeod RS, Silverberg MS, Williams CN, Siminovitch KA. Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12 and 16. Gastroenterology 1998;115(5):1062-1065.

Silverberg MS, Cattral M. Gastrointestinal complications of transplantation. Problems in General Surgery 1998;15(3):160-8.

Silverberg MS, Mikolainis S, Steinhart AH. Low bone mineral density in Crohn’s disease occurs independent of corticosteroid use. Gastroenterology 1998;114(4):A1078.

Silverberg MS, Murphy J, Steinhart AH, McLeod RS, Griffiths A, Mirea L, Bull SB, Williams CN, Greenberg GR, Cohen Z, Wade JA, Siminovitch KA. Contribution of HLA Class II genes to susceptibility to ulcerative colitis (UC) in a Canadian inflammatory bowel disease (IBD) population. Gastroenterology 1998;114(4):A2946.

Silverberg MS, Steinhart AH, McLeod RS, Griffiths A, Mirea L, Bull SB, Williams CN, Greenberg GR, Cohen Z, Siminovitch KA; Rioux JD, Daly MJ, Green T, Stone V, Hudson T, Lander ES. Genetic susceptibility in a Canadian inflammatory bowel disease (IBD) population. Gastroenterology 1998;114(4):A2945.

Steinhart AH, Girgrah N, McLeod RS. Reliability of a Crohn's disease clinical classification scheme based on disease behaviour. Inflammatory Bowel Diseases 1998;4:228-234.

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1997

Silverberg MS, Mikolainis S, Steinhart AH. Osteopenia in patients with Crohn's disease. Gastroenterology 1997; 112(4):A1092.

Silverberg MS, Steinhart AH. Osteoporosis in Inflammatory Bowel Disease: An Update. Crohn's and Colitis Foundation of America Journal Fall/Winter 1997: p.10-11.

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